SPEG_RAT Q63638
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UniProt:Q63638
Recommended name：Striated muscle-specific serine/threonine-protein kinase
EC number：EC:2.7.11.1
Alternative names：Aortic preferentially expressed protein 1 (APEG-1)
Cleaved into：
GeneID：
Gene names (primary )：Speg
Gene names (synonym )：Apeg1
Gene names (ORF )：
Length：3,259
Mass：354,166
Sequence：MQKARGTRGEDAGTRAPPSPGVPPKRAKVGAGRGVLVTGAGAGAPVFLRPLKNAAVCAGSDVRLRVVVSGTPEPSLSWFRDGQLLPTPVPEPSCLWLRNCGAQDAGVYSCSAQNERGKASCEAVLTVLEVRDSETAEDDISDVPGTQRLELRDDRAFSTPTGGSDTLVGTSLDTPPTSVTGTSEEQVSWWGSGQTVLEQEAGSGGGTRPLPGSPRQAQTTGAGPRHLGVEPLVRASRANLVGASWGSEDSLSVASDLYGSAFSLYRGRALSIHVSIPPSGLRREEPDLQPQPASDALRPRPALPPPSKSALLPPPSPRVGKRALPGSSAQPPATPTSPHRCTQEPSLPEDITTTEEKRGKKPKSSGPSLAGTVESRPQTPLSEASGRLSALGRSPRLVRAGSRILDKLQFFEERRRSLERSDSPPAPLRPWVPLRKARSLEQPKSEGGAAWDTPGASQEELRSPRGSVAERRRLFQQKAASLDERTRQRSATSDLELRFAQELGRIRRSTSREELVRSHESLRATLQRAPSPREPGEPPLFSRPSIPKTSRAVSPAATQPPPPSGAGKSGDETGRPRSRGPVGRTEPGEGPQQEIKRRDQFPLTRSRAIQECRSPVPPFTADPPESRTKAPSARKREPPAQAVRFLPWATPGVEDSVLPQTLEKNRAGPEAEKRLRRGPEEDGPWGAWDRRGTRSQGKGRRARPTSPELESSDDSYVSAGEEPLEAPVFEIPLQNMVVAPGADVLLKCIITANPPPQVSWKKDGSVLHSEGRLLIRAEGERHTLLLREAQAADAGSYTATATNELGQASCASSLAVRPGASTSPFSSPITSDEEYLSPPEEFPEPGETWSRTPTMKPSPSQDRDSSDSSSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDVGAGEMALFECLVAGPADVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTVKDELTCSARLTVRPSLAPLFTRLLEDVEVLEGRAARLDCKISGTPPPSVTWTHFGHPVNESENLRLRQDGGLHSLHIARVGSEDEGLYEVSATNTHGQAHCSAQLYVEEPRTAASGPSSKLEKMPSIPEEPEHGDLERLSIPDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDIHRLVFPAVGPQHAGVYKSVIANKLGKAACYAHLYVTDVVPGPPDGAPQVVAVTGRMVTLSWNPPRSLDMAIDPDSLTYTVQHQVLGSDQWTALVTGLREPEWAATGLKKGLHHIFRVLSSSGKSSSKPSAPSEPVQLLEHGPPLEEAPAVLDKQDIVYVVEGQPACVTVTFNHVEAQVVWRSCRGALLEPRTGVYELSQPDDDQYCLRICRVSRRDLGPLTCSARNRHGTKACSITLELAEAPRFESIMEDVEVGPGETARFAVVVEGKPLPDIMWYKDEVLLAESNHVSFVYEENECSLVVLSAGSQDGGVYTCTARNLAGEVSCKAELSVHSAQTAMEVEGVGEDEEHRGRRLSDYYDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHDCVLYFHEAFERRRGLVIVTELCTEELLERMARKPTVCESETRTYMRQVLEGIGYLHQSHVLHLDVKPENLLVWDGAGGEEQVRICDFGNAQELTPGEPQYCQFGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQDRLRPTAEETLEHPWFKTEAKGAEVSTDHLKLFLSRRRWQRSQISYKCHLVLRPIPELLRAPPERVWVAMPRRQPPSGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDIPTEDEALGTPEAGAATPMDWQEQGRAPSKDQEAPSPEALPSPGQESPDGPSPRRPELRRGSSAESALPRVGSREPGRSLHKAASVELPQRRSPSPGATRLTRGGLGEGEYAQRLQALRQRLLRGGPEDGKVSGLRGPLLESLGGRARDPRMARAASSEAAPHHQPPPESRGLQKSSSFSQGEAEPRGRHRRAGAPLEIPVARLGARRLQESPSLSALSETQPPSPALPSAPKPSITKSPEPSAATSRDSPQPPAPQPVPEKIPEPKPEPVRAAKPAQPPLALQMPAQSLTPYAQIMQSLQLSSPTLSPQVPPSEPKPHAAVFARVASPPPGASEKRVPSARIPPVLAEKVRVPTVPPRPGSSLSGSIENLESEAVFEAKFKRSRESPLSRGLRLLSRSRSEERGPFRGAEDDGIYRPSPAGTPLELVRRPERSRSVQDLRVAGEPGLVRRLSLSLSQKLRRTPPGQRHPAWESRSGDGESSEGGSSARGSPVLAVRRRLSSTLERLSSRLQRSGSSEDSGGASGRSTPLFGRLRRATSEGESLRRLGVPHNQLASQTGATTPSAESLGSEASGTSGSSAPGESRSRHRWGLSRLRKDKGLSQPNLSASVQEDLGHQYVPSESDFPPVFHIKLKDQVLLEGEAATLLCLPAACPTPRISWMKDKQSLRSEPSVVIVSCKDGRQLLSIPRASKRHAGLYECSATNVLGSITSSCTVAVARTPGKLAPPEVPQTYCDTALVLWKPGDSRAPCTYTLERRVDGESVWHPVSSGIPDCYYNVTQLPVGVTVRFRVACSNRAGQGPFSNPSEKVFIRGTQDSPAQSAAAPRDAPVTSGPTRAPPPDSPTSLVPTPPLAPQVSQASTLSPSTSSMSANQALSSLKAVGPPPATPPRKHRGLLATQQAEPSPPSILVTPSEHKSFVPDTGTLTPTSSPQGVKPAPSSSSLYMVTSFVSAPPDPQPPAPEPPPEPTKVTVRSLSPAKEVVSSPTPESTTLRQGPPQKPYTFLEEKARGRFGVVRSCRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERLMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYVVQLLQGLDYLHGRHVLHLDIKPDNLLLAADNALKIVDFGSAQPYNPQALKPLGHRTGTLEFMAPEMVRGDPIGSATDIWGAGVLTYIMLSGYSPFYEPDPQETEARIVGGRFDAFQLYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWLQDAYLMKLRRQTLTFTTNRLKEFLGEQRRRRAEAATRHKVLLRSYPGSP
Tissue specificity：Isoform 2 is highly expressed in differentiated arterial smooth muscle cells (ASMC) in the medial layer of the aorta. Weakly detected in brain and testis and to a lesser extent in organs rich in striated muscle or visceral smooth muscle.
Induction：
Developmental stage：
Protein families：