DPYL3_RAT   Q62952


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UniProt:Q62952

Recommended name:Dihydropyrimidinase-related protein 3

EC number:

Alternative names:Collapsin response mediator protein 4 (CRMP-4) TOAD-64/Ulip/CRMP TUC-4b

Cleaved into:

GeneID:

Gene names  (primary ):Dpysl3

Gene names  (synonym ):Crmp4

Gene names  (ORF ):

Length:570

Mass:61,967

Sequence:MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVMPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLSKEKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQVHAENGDIIAQEQARMLEMGITGPEGHVLSRPEELEAEAVFRAITVASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDSDLVIWDPDAVKIVSAKNHQSVAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSTRGSPTRPNPPVRNLHQSGFSLSGTQVDEGVRSASKRIVAPPGGRSNITSLS

Tissue specificity:Isoform 2 is expressed in growth cones. Up-regulated in motor neurons during axonal regeneration after sciatic nerve lesion. Overexpression of isoform 2 increased neurite extension and branching. Isoform 1 is expressed throughout neurons and their axons. 1

Induction:

Developmental stage:At 17 dpc, isoform 2 is expressed in the CNS and PNS. Isoform 2 is expressed at high levels in the dorsal root ganglia, trigeminal ganglia, and throughout the spinal cord with the highest level in the ventral horn. 1

Protein families:


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