KCNQ4_RAT   Q9JK96


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UniProt:Q9JK96

Recommended name:Potassium voltage-gated channel subfamily KQT member 4

EC number:

Alternative names:

Cleaved into:

GeneID:298496

Gene names  (primary ):Kcnq4

Gene names  (synonym ):

Gene names  (ORF ):

Length:695

Mass:77,061

Sequence:MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIIRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDTSRAYLTATWYYYDSILPSFRELALLFEHIQRARNGGLRPLEVRRAPVPDGAASRYPPVATCHRPGSASFCPGESSRMGIKDRIRMSSSQKRTGPSKQHLAPPPIPTSPSSEQVGEASSPSKVQKSWSFNDRTRFRASLRLKPRCSTEEGPSEEVAEEKSYQCELTVDDVMPTVKTVIRSVRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQARVDQIVGRGPGDRKTREKGDKGPSDTEAVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGTVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD

Tissue specificity:Expressed in both the inner (IHCs) and the outer hair cells (OHCs) of the cochlea. Reciprocal longitudinal gradients of expression is present in IHCs and OHCs. The strongest expression in IHCs is in the base of the cochlea and in the apex for OHCs. A basal to apical gradient of expression is also present in both type I and type II spiral ganglion cells. 1

Induction:

Developmental stage:At P0 expression is primarily in the basal hook to lower middle turn of the cochlea and progressively expands toward the apex over time. By P8, the expression is evident in both IHCs and OHCs along the entire length of the cochlea. Then the adult pattern begins to emerge, as expression in basal OHCs and in apical IHCs decreases. 1

Protein families:


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