S22A1_RAT Q63089
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UniProt:Q63089
Recommended name：Solute carrier family 22 member 1 1 Publication
EC number：
Alternative names：
Cleaved into：
GeneID：
Gene names (primary )：Slc22a1
Gene names (synonym )：Oct1
Gene names (ORF )：
Length：556
Mass：61,541
Sequence：MPTVDDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNPGVAELSQRCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLGPCEHGWVYDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVGLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPADLKMLCLEEDASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLTAGAMTLLLPETKGVALPETIEEAENLGRRKSKAKENTIYLQVQTGKSSST
Tissue specificity：Expressed in kidney cortex in S1, S2 segments of renal proximal tubules as well as in kidney medulla (PubMed:10997918, PubMed:11083459, PubMed:11758759, PubMed:11792693, PubMed:16272756, PubMed:7990927, PubMed:9195965, PubMed:9808712, PubMed:9830022). Expressed throughout the liver lobuli, in hepatocytes surrounding the central veins (PubMed:16272756, PubMed:7990927, PubMed:9195965, PubMed:9703985, PubMed:9830022). Expressed in enterocytes of villi and crypts in small intestine (PubMed:7990927, PubMed:9195965, PubMed:9830022). Expressed in brain, in some white matter regions like the corpus callosum and in the granular layer of the cerebellum (PubMed:11792693, PubMed:16581093). Expressed in Sertoli cells in testis (PubMed:17616214). Expressed in colon (PubMed:7990927, PubMed:9195965). Expressed in tracheal and bronchial ciliated epithelium in the respiratory tract (PubMed:15817714). Expressed in spleen, moderately in skin, and weakly in the gastrointestinal tract, lung, thymus, muscle, and prostate (PubMed:11792693). 12 s
Induction：Down-regulated in obstructive cholestasis. Up-regulated by treatment with pregnenolone-16 alpha-carbonitrile (PCN) and by overexpression of pregnane X receptor (PXR). 2 Publications
Developmental stage：Expressed in kidney cortex and medulla (PubMed:9195965). Expressed in intestine, liver and colon (PubMed:9195965). 1
Protein families：