FOLH1_RAT P70627
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UniProt:P70627
Recommended name：Glutamate carboxypeptidase 2
EC number：EC:3.4.17.21
Alternative names：Folate hydrolase 1 Folylpoly-gamma-glutamate carboxypeptidase (FGCP) Glutamate carboxypeptidase II (GCPII) Membrane glutamate carboxypeptidase (mGCP) N-acetylated-alpha-linked acidic dipeptidase I (NAALADase I) More alternative names
Cleaved into：
GeneID：
Gene names (primary )：Folh1
Gene names (synonym )：Naalad1
Gene names (ORF )：
Length：752
Mass：84,540
Sequence：MWNAQQDSDSAEALGRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSYPGMKKAFLQELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLSYPNKTHPNYISIINEDGNEIFKTSLAELSPPGYENISDVVPPYSAFSPQGTPEGDLVYVNYARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGIILYSDPADYFVPGVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAVGLPSIPVHPIGYDDAQKLLEHMGGSAPPDSSWKGGLKVPYNVGPGFAGNFSKQKVKLHIHSYNKVTRIYNVIGTLKGAVEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRTFGTLKKKGWRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMHSLVYNLTKELPSPDEGFEGKSLYDSWKEKSPSTEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWKNNKVSSYPLYHSVYETYELVEKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQSYAVALKKHAETIYNISMNHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQDLDKSNPILLRILNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDINNKVDTSKAWREVKRQISIAAFTVQAAAETLREVD
Tissue specificity：Widely expressed throughout brain regions with highest levels in the hippocampus, dentate gyrus, priform cortex, choroid plexus of ventricles, pineal gland, anterior lobe of the pituitary gland and supraoptic nucleus. High levels also found in the cerebral cortex, substantia nigra, pontine nucleus and the granule cell layer of cerebellum. Highly expressed in astrocytes and non-myelinating Schwann cells. Also expressed in kidney, localizing to the proximal brush border of the renal tube.
Induction：
Developmental stage：
Protein families：peptidase M28 family