SORL_RAT P0DSP1
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UniProt:P0DSP1
Recommended name：Sortilin-related receptor
EC number：
Alternative names：
Cleaved into：
GeneID：300652
Gene names (primary )：Sorl1
Gene names (synonym )：
Gene names (ORF )：
Length：2,215
Mass：247,316
Sequence：MATRSSRRESRLPFLFTLVALLPPGALGGGWTQRLHGGGAPLPQDRGFFVVQGDPHELRLGTHGDAWGASPAARKPLRTRRSAALQPQPIQVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALTRPKSSDVYVSYDYGKSFNKISEKLNFGVGNSSEAVISQFYHSPADNKRYIFVDAYARYLWITFDFGSTIHGFSIPFRAADLLLHSKASNLLLGFDSSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDQPNTIYIERHEPFGFSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYLFATKVVHLPGSQQQSSVQLWVSFGRKPMRAAQFVTKHPINEYYIADASEDQVFVCVSHSNNSTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMSEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYSTNEGETWKTFVFSEKPVFVYGLLTEPGEKSTVFTIFGSNKESVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDISLEVCVPDPEFSGKPYSPPVPCPVGSSYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAMRKSIYRYDLASGATEQLPLSGLRAAVALDFDYEHNCLYWSDLALDTIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYRLVSEDVKWPNGISVDGHWIYWTDAYLDCIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSRSQVETLASQLTGLMDMKIFYKGKNAGSNACIPQPCSLLCLPKANNSKSCRCPEGVASSVLPSGYLMCDCPQGYERKNNTCVKEENTCLRNQYHCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDADTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCHNGHCIPQRWACDGDADCQDGSDEDPISCEKKCNGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHCEPFCTRFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDATFAGCSQDPEFHKECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFHCENGRCIPNRWKCDRENDCGDWSDEKDCGDSHIFPSPTPGPSTCLPNYFRCSSGACVMGTWVCDGYRDCADGSDEEACPSLANSTAASTPTQLGQCDRFEFECRQPKKCIPNWKRCDGHQDCQDGQDEANCPTHSTLTCMSREFKCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWIADFSGDVTLTWTRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTSTVLKVLKPDTTYQVKVQVHCLSKVHNTNDFVTLRTPEGLPDAPRNLQLSLNSEEEGVILGHWAPPVHTHGLIREYIVEYSRSGSKMWASQRAASNSTEIKNLLLNALYTVRVAAVTSRGIGNWSDSKSITTTKGKVIQAPNIHIDSYDENSLSFTLTMDGDIKVNGYVVNLFWSFDAHKQEKKTLNFRGGSSLSHKVSNLTAHTSYEVSAWAKTDLGDSPLAFEHILTRGISPPAPSLKAKAINQTAVECIWTGPKNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVLIPYQGPSSDYVVVKMIPDSRLPPRHLHAVQIGKTSAVIKWESPYDSPDQDLFYAIAVKDLIRKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKQFNETRGYEIHMFDSAVNLTAYLGNTTDNFFKVSNLKMGHNYTFTVQARCLFGSQICGEPAVLLYDELSSGGDATVVQTARSTDVAAVVVPILFLILLSLGVGFAVLYTKHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA
Tissue specificity：Highly expressed in the cerebral cortex, the pyramidal cells of the CA region of the hippocampus, the granular cells of the dentate gyrus, the Purkinje cell layer of the cerebellum and the piriform cortex. Lower levels were detected over the mitral cell layer of the olfactory bulb, the nuclei of the amygdala, the nucleus reticularis of the thalamus and several hypothalamic nuclei. In the brainstem weak expression in the pontine nuclei. In the central nervous system, expression is restricted to neurons (PubMed:9510025). Expressed in intimal smooth muscle cell after vascular injury (PubMed:17332490). 2 s
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