TRI63_RAT Q91Z63
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UniProt:Q91Z63
Recommended name:E3 ubiquitin-protein ligase TRIM63
EC number:EC:2.3.2.27
Alternative names:Muscle-specific RING finger protein 1 (MuRF-1; MuRF1) RING-type E3 ubiquitin transferase TRIM63 Curated Tripartite motif-containing protein 63
Cleaved into:
GeneID:140939
Gene names (primary ):Trim63
Gene names (synonym ):Murf1
Gene names (ORF ):
Length:351
Mass:39,723
Sequence:MDYKSGLIPDGNAMENLEKQLICPICLEMFTKPVVILPCQHNLCRKCANDIFQAANPYWTNRGGSVSMSGGRFRCPSCRHEVIMDRHGVYGLQRNLLVENIIDIYKQECSSRPLQKGSHPMCKEHEDEKINIYCLTCEVPTCSLCKVFGAHQACEVAPLQSIFQGQKTELSNCISMLVAGNDRVQTIISQLEDSCRVTKENSHQVKEELSHKFDALYAILDEKKSELLQRITQEQEEKLDFIEALILQYREQLEKSTKLVETAIQSLDEPGGATFLLSAKPLIKSIVEASKGCQLGKTEQGFENMDYFTLNLEHIAEALRAIDFGTDEEEEFTEEEEEEDQEEGVSTEGHQ
Tissue specificity:Muscle specific. Selectively expressed in heart and skeletal muscle. 1
Induction:
Developmental stage:By interleukin-1, dexamethasone, lipolysaccharide and indinavir. Up-regulated upon muscle denervation, immobilization and unweighting and more generally upon muscle atrophy. Up-regulated upon sepsis. Down-regulated upon aging. 6 s
Protein families: