REST_RAT O54963
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UniProt:O54963
Recommended name：RE1-silencing transcription factor
EC number：
Alternative names：
Cleaved into：
GeneID：
Gene names (primary )：Rest
Gene names (synonym )：Nrsf
Gene names (ORF )：
Length：1,069
Mass：117,126
Sequence：MATQVMGQSSGGGSLFNNSGNMGMALPNDMYDLHDLSKAELAAPQLIMLANVALTGEVNGSCCDYLVGEERQMAELMPVGDNHFSDSEGEGLEESAELKGDPSGLDNMELRSLELSVVEPQPVFEASAAPEVYSSNKDPAPEAPVAEDKCKNLKAKPFRCKPCQYEAESEEQFVHHIRVHSAKKFFVEESAEKQAKARESGASPSEEGEFSKGPIRCDRCGYNTNRYDHYTAHLKHHLRAGDNERVYKCIICTYTTVSEYHWRKHLRNHFPRKVYTCSKCNYFSTEKNNYVQHVRTHTGERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCDQCNYVASNQHEVTRHARQVHNGPKPLNCPHCDYKTADRSNFKKHVELHVNPRQFNCPVCDYAASKKCNLQYHFKSKHPTCPSKTMDVSKVKLKKTKRREADLHRDAAAAATEQTDTEQAKTKGVDASARRSERPVKGVGKDVPKEKKPCSNASVVQVTTRTRKSAVETKAAEGKHTDGQTGNNAEKSSKAKKSKRKMDAEAHPSVEPVTEGPVTKKKKTESKPKTSGEVPKGSRVEDRKADKQQSASIKKGGKKTALKTKTAKKGSKLAPKWVGHTEPSSEMAQGGESPVPALTQAVVTPSGSTQTELSSPMDIAQTEPAQMDVSQTGPPQVQRPLPVEPAQLEPSPPQEPPQVEPPACVEPPPPVEPPCPMEPAEMEPSPPMEPSQVEPPPHLEPPLPMELPQVELPPVEDCQKELPPVEHAQTKVAQTGPTQVGAVQEEPLFCLRATSSQANQKVISPKDRAKEKLSVLSEMARQEQVLIEVGLVPVRDSQLLKASKSAPDLPAPPSPLPKGHLRREETPKDQEMFSDGEGNKVSPLEKGGTEEAGESRAELAAPMESTSALSSEQSSNAPDGETLHSECQADSTAVCEMEVDTEQKTDRVPLKDSAVEPVSPLNPRVDPEAAAPAVVASPPITLAESQEIDEDEGIHSHDGSDLSDNMSEGSDDSGLHGARPAPQEATSKSGKEGLAVKVTEGEFVCIFCDRSFRKEKDYSKHLNRHLVNVYFLEEAAEEQE
Tissue specificity：Expressed in the hippocampus including the granule cell layer of the dentate gyrus, the pyramidal cell layers of CA1 and CA3, the apical and basilar dendrite layers of the stratum radiatum and stratum oriens of CA1, the stratum lucidum and stratum oriens of CA3 and in astroglia (at protein level) (PubMed:12657670, PubMed:22371606, PubMed:22960932). Expressed in the brain, with the highest levels in the neurons of hippocampus, pons/medulla and midbrain (PubMed:25108103, PubMed:9454838). 5 s
Induction：Levels decrease during embryonic brain development (PubMed:9454838). Expressed during postnatal days P3 to P60, with an increase in expression at postnatal day P14-P15 (PubMed:22960932). Increased abundance in the nucleus at P14-P15 relative to P9 (PubMed:22960932). 2 Publications
Developmental stage：Up-regulated by kainic acid (PubMed:9454838). Up-regulated in the pyramidal cell layer of CA1 in the hippocampus by global ischemia (PubMed:12657670, PubMed:22371606, PubMed:25108103). Down-regulated in the hippocampus by maternal deprivation (PubMed:22960932). 5 s
Protein families：