SPTC1_RAT D4A2H2
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UniProt:D4A2H2
Recommended name：Serine palmitoyltransferase 1 Curated
EC number：EC:2.3.1.50
Alternative names：Long chain base biosynthesis protein 1 (LCB 1) Serine-palmitoyl-CoA transferase 1 (SPT 1; SPT1)
Cleaved into：
GeneID：361213
Gene names (primary )：Sptlc1
Gene names (synonym )：Lcb1
Gene names (ORF )：rCG_44191
Length：473
Mass：52,549
Sequence：MATVAEQWVLVEMVQALYEAPAYHLILEGILILWIIRLVFSKTYKLQERSDLTAKEKEELIEEWQPEPLVPPVSRNHPALNYNIVSGPPTHNIVVNGKECVNFASFNFLGLLANPRVKAAAFASLKKYGVGTCGPRGFYGTFDVHLDLEERLAKFMKTEEAIIYSYGFSTIASAIPAYSKRGDIVFVDSAACFAIQKGLQASRSDIKLFKHNDVADLERLLKEQEIEDQKNPRKARVTRRFIVAEGLYMNTGTICPLPELVRLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGISIDDIDLISANMENALASVGGFCCGRSFVVDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKKKCQTIHKSLQGVSGLKVVGESLCPALHLQLEESTGSRERDMKLLQEIVEQCMNKGIALTQARYLDKEEKCLPPPSIRVVVTVEQTDEELQRAAATIREAAQAVLL
Tissue specificity：Expressed in astrocytes. 1
Induction：
Developmental stage：Expression in increased by palmitate at the protein level, but not at the mRNA level (PubMed:21994399). Expression is down-regulated by microRNA miR-137 and miR-181c (at protein level) (PubMed:21994399). 1
Protein families：class-II pyridoxal-phosphate-dependent aminotransferase family