S22A3_RAT O88446
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UniProt:O88446
Recommended name：Solute carrier family 22 member 3 By Similarity
EC number：
Alternative names：
Cleaved into：
GeneID：29504
Gene names (primary )：Slc22a3
Gene names (synonym )：Oct3
Gene names (ORF )：
Length：551
Mass：61,050
Sequence：MPTFDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPEEEWNLTTPELHVPAERRGQGHCHRYLLEDTNTSSELSCDPLAAFPNRSAPLVPCSGDWRYVETHSTIVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIVYLISCFGVGITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLSSNYSEITVTDEEVSNPSCLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGLIGGNLYMDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIPWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLGSSQLHQCGRKKKTQVSTSNV
Tissue specificity：Highly expressed in placenta (PubMed:9632645, PubMed:9830022). Expressed in intestine, hear, kidney and lung (PubMed:9632645). Widely expressed in brain, particularly in hippocampus, cerebellum, cerebral cortex (PubMed:9632645, PubMed:9830022). In the brain, expressed predominantly in regions located at the brain-cerebrospinal fluid border, with expression extending to regions that belong to monoaminergic pathways such as raphe nuclei, striatum and thalamus (PubMed:16581093). In brain, expressed in neurons and glial cells of amygdala (PubMed:27659446). Expression is low in kidney and lung and undetectable in liver. Expressed in Sertoli cells in testis (PubMed:17616214). Expressed in tracheal and bronchial epithelium of the respiratory tract, where it localizes to the apical membrane of ciliated and brush cells, and in basal cells (PubMed:15817714). 6 s
Induction：
Developmental stage：
Protein families：major facilitator (TC 2.A.1) superfamily