HMCS2_HUMAN P54868
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UniProt:P54868
Recommended name：Hydroxymethylglutaryl-CoA synthase, mitochondrial
EC number：EC:2.3.3.10
Alternative names：(HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase)
Cleaved into：
GeneID：3158
Gene names (primary )：HMGCS2
Gene names (synonym )：
Gene names (ORF )：
Length：508
Mass：56635
Sequence：MQRLLTPVKRILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARRPV
Tissue specificity：Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas. Very low expression in heart and skeletal muscle (PubMed:7893153, PubMed:21952825, PubMed:16940161). Not detected in brain (PubMed:21952825). {ECO:0000269|PubMed:16940161, ECO:0000269|PubMed:21952825, ECO:0000269|PubMed:7893153}.; [Isoform 3]: Highest expression detected in heart and skeletal muscle. {ECO:0000269|PubMed:21952825}.
Induction：
Developmental stage：
Protein families：Thiolase-like superfamily, HMG-CoA synthase family