HMGCL_HUMAN P35914
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UniProt:P35914
Recommended name：Hydroxymethylglutaryl-CoA lyase, mitochondrial
EC number：EC:4.1.3.4
Alternative names：(HL) (HMG-CoA lyase) (3-hydroxy-3-methylglutarate-CoA lyase)
Cleaved into：
GeneID：3155
Gene names (primary )：HMGCL
Gene names (synonym )：
Gene names (ORF )：
Length：325
Mass：34360
Sequence：MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
Tissue specificity：Highest expression in liver. Expressed in pancreas, kidney, intestine, testis, fibroblasts and lymphoblasts. Very low expression in brain and skeletal muscle. The relative expression of isoform 2 (at mRNA level) is highest in heart (30%), skeletal muscle (22%), and brain (14%). {ECO:0000269|PubMed:21952825}.
Induction：
Developmental stage：
Protein families：HMG-CoA lyase family