TFF1_HUMAN P04155
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UniProt:P04155
Recommended name：Trefoil factor 1
EC number：
Alternative names：(Breast cancer estrogen-inducible protein) (PNR-2) (Polypeptide P1.A) (hP1.A) (Protein pS2)
Cleaved into：
GeneID：7031
Gene names (primary )：TFF1
Gene names (synonym )：BCEI PS2
Gene names (ORF )：
Length：84
Mass：9150
Sequence：MATMENKVICALVLVSMLALGTLAEAQTETCTVAPRERQNCGFPGVTPSQCANKGCCFDDTVRGVPWCFYPNTIDVPPEEECEF
Tissue specificity：Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level). {ECO:0000269|PubMed:15924415, ECO:0000269|PubMed:16308573, ECO:0000269|PubMed:16718800, ECO:0000269|PubMed:17143957, ECO:0000269|PubMed:17242463, ECO:0000269|PubMed:3041593, ECO:0000269|PubMed:3838275}.
Induction：
Developmental stage：
Protein families：