AACT_HUMAN P01011
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UniProt:P01011
Recommended name：Alpha-1-antichymotrypsin
EC number：
Alternative names：(ACT) (Cell growth-inhibiting gene 24/25 protein) (Serpin A3)
Cleaved into：Alpha-1-antichymotrypsin His-Pro-less
GeneID：12
Gene names (primary )：SERPINA3
Gene names (synonym )：AACT
Gene names (ORF )：GIG24 GIG25
Length：423
Mass：47651
Sequence：MERMLPLLALGLLAAGFCPAVLCHPNSPLDEENLTQENQDRGTHVDLGLASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALFILPDQDKMEEVEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLMIIVPTDTQNIFFMSKVTNPKQA
Tissue specificity：Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains. {ECO:0000269|PubMed:3257719, ECO:0000269|PubMed:9880565}.
Induction：
Developmental stage：
Protein families：Serpin family