GDNF_HUMAN P39905
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UniProt:P39905
Recommended name：Glial cell line-derived neurotrophic factor
EC number：
Alternative names：(hGDNF) (Astrocyte-derived trophic factor) (ATF)
Cleaved into：
GeneID：2668
Gene names (primary )：GDNF
Gene names (synonym )：
Gene names (ORF )：
Length：211
Mass：23720
Sequence：MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
Tissue specificity：In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. {ECO:0000269|PubMed:22081608, ECO:0000269|PubMed:7867768}.
Induction：By cAMP, 12-O-tetradecanoylphorbol-13-acetate (TPA) and FGF2. {ECO:0000269|PubMed:9811930}.
Developmental stage：
Protein families：TGF-beta family, GDNF subfamily