TRIB3_HUMAN Q96RU7
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UniProt:Q96RU7
Recommended name：Tribbles homolog 3
EC number：
Alternative names：(TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B)
Cleaved into：
GeneID：57761
Gene names (primary )：TRIB3
Gene names (synonym )：C20orf97 NIPK SKIP3 TRB3
Gene names (ORF )：
Length：358
Mass：39578
Sequence：MRATPLAAPAGSLSRKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPLSPPTAPDRATAVATASRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVVPDGLGLDEAREEEGDREVVLYG
Tissue specificity：Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney. {ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:12743605, ECO:0000269|PubMed:15299019}.
Induction：By hypoxia, TNF, and by nutrient starvation. Expression is PI 3-kinase and/or NF-kappa-B-dependent. Induced by ER stress via ATF4-DDIT3/CHOP pathway and can downregulate its own induction by repression of ATF4-DDIT3/CHOP functions. {ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:12743605, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:16129579}.
Developmental stage：
Protein families：Protein kinase superfamily, CAMK Ser/Thr protein kinase family, Tribbles subfamily