OLR1_HUMAN P78380
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UniProt:P78380
Recommended name：Oxidized low-density lipoprotein receptor 1
EC number：
Alternative names：(Ox-LDL receptor 1) (C-type lectin domain family 8 member A) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (hLOX-1) (Lectin-type oxidized LDL receptor 1)
Cleaved into：Oxidized low-density lipoprotein receptor 1, soluble form
GeneID：4973
Gene names (primary )：OLR1
Gene names (synonym )：CLEC8A LOX1
Gene names (ORF )：
Length：273
Mass：30959
Sequence：MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ
Tissue specificity：Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level. {ECO:0000269|PubMed:12354387, ECO:0000269|PubMed:9052782, ECO:0000269|PubMed:9828121}.
Induction：By inflammatory cytokines such as TNF, IFNG/IFN-gamma, IL6/interleukin-6 and by pathological conditions such as hyperlipidemia, hypertension and diabetes mellitus. Up-regulated in atherosclerotic lesions, by oxLDL, reactive oxygen species and fluid shear stress, suggesting that it may participate in amplification of oxLDL-induced vascular dysfunction. {ECO:0000269|PubMed:12878212, ECO:0000269|PubMed:9828121}.
Developmental stage：
Protein families：