CGAS_HUMAN Q8N884
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UniProt:Q8N884
Recommended name：Cyclic GMP-AMP synthase
EC number：EC:2.7.7.86
Alternative names：(cGAMP synthase) (cGAS) (h-cGAS) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1)
Cleaved into：
GeneID：115004
Gene names (primary )：CGAS
Gene names (synonym )：C6orf150 MB21D1
Gene names (ORF )：
Length：522
Mass：58814
Sequence：MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGKFGPARKSGSRQKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGSCRQRGARCSTKPRPPPGPWDVPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
Tissue specificity：Expressed in the monocytic cell line THP1. {ECO:0000269|PubMed:23258413}.
Induction：By type I interferons. {ECO:0000269|PubMed:21478870}.
Developmental stage：
Protein families：Mab-21 family