SBP1_HUMAN Q13228
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UniProt:Q13228
Recommended name：Methanethiol oxidase
EC number：EC:1.8.3.4
Alternative names：(MTO) (56 kDa selenium-binding protein) (SBP56) (SP56) (Selenium-binding protein 1)
Cleaved into：
GeneID：8991
Gene names (primary )：SELENBP1
Gene names (synonym )：SBP
Gene names (ORF )：
Length：472
Mass：52391
Sequence：MATKCGNCGPGYSTPLEAMKGPREEIVYLPCIYRNTGTEAPDYLATVDVDPKSPQYCQVIHRLPMPNLKDELHHSGWNTCSSCFGDSTKSRTKLVLPSLISSRIYVVDVGSEPRAPKLHKVIEPKDIHAKCELAFLHTSHCLASGEVMISSLGDVKGNGKGGFVLLDGETFEVKGTWERPGGAAPLGYDFWYQPRHNVMISTEWAAPNVLRDGFNPADVEAGLYGSHLYVWDWQRHEIVQTLSLKDGLIPLEIRFLHNPDAAQGFVGCALSSTIQRFYKNEGGTWSVEKVIQVPPKKVKGWLLPEMPGLITDILLSLDDRFLYFSNWLHGDLRQYDISDPQRPRLTGQLFLGGSIVKGGPVQVLEDEELKSQPEPLVVKGKRVAGGPQMIQLSLDGKRLYITTSLYSAWDKQFYPDLIREGSVMLQVDVDTVKGGLKLNPNFLVDFGKEPLGPALAHELRYPGGDCSSDIWI
Tissue specificity：Widely expressed. Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients. {ECO:0000269|PubMed:14991897, ECO:0000269|PubMed:16223876, ECO:0000269|PubMed:16380993, ECO:0000269|PubMed:16645984, ECO:0000269|PubMed:29255262, ECO:0000269|PubMed:9679983}.
Induction：Down-regulated by androgen in prostate cancer cells. {ECO:0000269|PubMed:9679983}.
Developmental stage：
Protein families：Selenium-binding protein family