PDK2_HUMAN Q15119
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UniProt:Q15119
Recommended name：[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
EC number：EC:2.7.11.2
Alternative names：(Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)
Cleaved into：
GeneID：5164
Gene names (primary )：PDK2
Gene names (synonym )：PDHK2
Gene names (ORF )：
Length：407
Mass：46154
Sequence：MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
Tissue specificity：Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung. {ECO:0000269|PubMed:7499431}.
Induction：Down-regulated by insulin. Up-regulated by reactive oxygen species and cigarette smoke extract. Up-regulated by PPARD. {ECO:0000269|PubMed:17669420, ECO:0000269|PubMed:21283817, ECO:0000269|PubMed:9787110}.
Developmental stage：
Protein families：PDK/BCKDK protein kinase family