PTEN_HUMAN P60484
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UniProt:P60484
Recommended name：Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
EC number：EC:3.1.3.16
Alternative names：(Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
Cleaved into：
GeneID：5728
Gene names (primary )：PTEN
Gene names (synonym )：MMAC1 TEP1
Gene names (ORF )：
Length：403
Mass：47166
Sequence：MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
Tissue specificity：Expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas. {ECO:0000269|PubMed:9090379}.
Induction：Down-regulated by TGFB1. {ECO:0000269|PubMed:9187108}.
Developmental stage：
Protein families：PTEN phosphatase protein family