SIGIR_HUMAN Q6IA17
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UniProt:Q6IA17
Recommended name：Single Ig IL-1-related receptor
EC number：
Alternative names：(Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8)
Cleaved into：
GeneID：59307
Gene names (primary )：SIGIRR
Gene names (synonym )：
Gene names (ORF )：UNQ301/PRO342
Length：410
Mass：45679
Sequence：MPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCSHSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWRPGSVTPSSDFWKEVQLALPRKVQYRPVEGDPQTQLQDDKDPMLILRGRVPEGRALDSEVDPDPEGDLGVRGPVFGEPSAPPHTSGVSLGESRSSEVDVSDLGSRNYSARTDFYCLVSKDDM
Tissue specificity：Mainly expressed in epithelial tissues such as kidney, lung and gut. {ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:21077278}.
Induction：Down-regulated during inflammation by inhibition of an SP1-mediated pathway. {ECO:0000269|PubMed:21077278}.
Developmental stage：
Protein families：Interleukin-1 receptor family