KISS1_HUMAN Q15726
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UniProt:Q15726
Recommended name：Metastasis-suppressor KiSS-1
EC number：
Alternative names：(Kisspeptin-1)
Cleaved into：Metastin (Kisspeptin-54); Kisspeptin-14; Kisspeptin-13; Kisspeptin-10
GeneID：3814
Gene names (primary )：KISS1
Gene names (synonym )：
Gene names (ORF )：PP5098
Length：138
Mass：14705
Sequence：MNSLVSWQLLLFLCATHFGEPLEKVASVGNSRPTGQQLESLGLLAPGEQSLPCTERKPAATARLSRRGTSLSPPPESSGSPQQPGLSAPHSRQIPAPQGAVLVQREKDLPNYNWNSFGLRFGKREAAPGNHGRSAGRG
Tissue specificity：Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast. {ECO:0000269|PubMed:11385580, ECO:0000269|PubMed:12414911, ECO:0000269|PubMed:15020672}.
Induction：Down-regulated during the progression of melanoma in vivo. Diminishes MMP9 expression by effecting reduced NF-kappa-B binding to the promoter. {ECO:0000269|PubMed:11606374}.
Developmental stage：
Protein families：KISS1 family