LOX12_HUMAN P18054
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UniProt:P18054
Recommended name：Polyunsaturated fatty acid lipoxygenase ALOX12
EC number：EC:1.13.11.-
Alternative names：(Arachidonate(12S)-lipoxygenase) (12S-LOX) (12S-lipoxygenase) (Arachidonate(15S)-lipoxygenase) (Linoleate(13S)-lipoxygenase) (Lipoxin synthase 12-LO) (Platelet-type lipoxygenase 12)
Cleaved into：
GeneID：239
Gene names (primary )：ALOX12
Gene names (synonym )：12LO LOG12
Gene names (ORF )：
Length：663
Mass：75694
Sequence：MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNALDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKAGALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRRQPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENSVTI
Tissue specificity：Expressed in vascular smooth muscle cells. {ECO:0000269|PubMed:23578768}.
Induction：Down-regulated upon starvation, by UV-irradiation and 15-lipoxygenase metabolites. {ECO:0000269|PubMed:18755188, ECO:0000269|PubMed:8912711}.
Developmental stage：
Protein families：Lipoxygenase family