GRHL2_HUMAN Q6ISB3
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UniProt:Q6ISB3
Recommended name：Grainyhead-like protein 2 homolog
EC number：
Alternative names：(Brother of mammalian grainyhead) (Transcription factor CP2-like 3)
Cleaved into：
GeneID：79977
Gene names (primary )：GRHL2
Gene names (synonym )：BOM TFCP2L3
Gene names (ORF )：
Length：625
Mass：71105
Sequence：MSQESDNNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESSAIIPVSGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMYDQTSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGGSVLVKRMFRPMEEEFGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNIIEHYSNEDTFILNMESMVEGFKVTLMEI
Tissue specificity：Expressed in keratinocytes (at protein level). Highly expressed in placenta, prostate, brain and kidney. Lower-level expression in a variety of epithelial tissues such as thymus, lung, salivary gland, mammary gland and digestive tract. Expressed in the cochlear. Expressed in corneal epithelial cells, but not in the endothelium or stroma (PubMed:29499165). {ECO:0000269|PubMed:12175488, ECO:0000269|PubMed:12393799, ECO:0000269|PubMed:20978075, ECO:0000269|PubMed:25152456, ECO:0000269|PubMed:29499165}.
Induction：Expressed in proliferating cells, the expression decreases during senescence. In keratinocytes, expression levels decrease upon calcium exposure. {ECO:0000269|PubMed:20938050, ECO:0000269|PubMed:23254293}.
Developmental stage：
Protein families：Grh/CP2 family, Grainyhead subfamily