AURKA_HUMAN O14965
We list detailed information on various proteins on this webpage, which EnkiLife references when developing protein-related products. The protein data is sourced from UniProt, and since UniProt updates its information periodically, the data on our webpage may not always be up-to-date or may contain inaccuracies. If you notice any errors while browsing, we warmly welcome your feedback. Additionally, if you have any suggestions regarding any aspect of our website, please feel free to share them with us. As a token of our appreciation, we will offer a free product or a discount voucher for purchases to scientists who provide feedback. Please contact us at Email: order@enkilife.com; to share your feedback and get your rewards.
UniProt:O14965
Recommended name：Aurora kinase A
EC number：EC:2.7.11.1
Alternative names：(Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A)
Cleaved into：
GeneID：6790
Gene names (primary )：AURKA
Gene names (synonym )：AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6
Gene names (ORF )：
Length：403
Mass：45809
Sequence：MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Tissue specificity：Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
Induction：Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly after. {ECO:0000269|PubMed:11790771, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:9153231, ECO:0000269|PubMed:9606188}.
Developmental stage：
Protein families：Protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily