BLK_HUMAN P51451
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UniProt:P51451
Recommended name:Tyrosine-protein kinase Blk
EC number:EC:2.7.10.2
Alternative names:(B lymphocyte kinase) (p55-Blk)
Cleaved into:
GeneID:640
Gene names (primary ):BLK
Gene names (synonym ):
Gene names (ORF ):
Length:505
Mass:57706
Sequence:MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP
Tissue specificity:Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. {ECO:0000269|PubMed:19667185}.
Induction:Expression is under the control of NF-kappa-B as well as the B-cell specific transcription factors PAX5 and EBF1. {ECO:0000269|PubMed:10553071}.
Developmental stage:
Protein families:Protein kinase superfamily, Tyr protein kinase family, SRC subfamily