CDK1_HUMAN P06493
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UniProt:P06493
Recommended name：Cyclin-dependent kinase 1
EC number：EC:2.7.11.22
Alternative names：(CDK1) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Cleaved into：
GeneID：983
Gene names (primary )：CDK1
Gene names (synonym )：CDC2 CDC28A CDKN1 P34CDC2
Gene names (ORF )：
Length：297
Mass：34095
Sequence：MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
Tissue specificity：Isoform 2 is found in breast cancer tissues.
Induction：Follows a cyclic expression; during interphase, accumulates gradually following G1, S to reach a critical threshold at the end of G2, which promotes self-activation and triggers onset of mitosis. Induced transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis, but later repressed. Triggered by CKS1B during mitotic entry in breast cancer cells. Down-regulated under genotoxic stresses triggered by PKR/EIF2AK2-mediated phosphorylation. {ECO:0000269|PubMed:17459720, ECO:0000269|PubMed:18056467}.
Developmental stage：
Protein families：Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily