SPI1_HUMAN P17947
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UniProt:P17947
Recommended name:Transcription factor PU.1
EC number:
Alternative names:(31 kDa-transforming protein)
Cleaved into:
GeneID:6688
Gene names (primary ):SPI1
Gene names (synonym ):
Gene names (ORF ):
Length:270
Mass:31083
Sequence:MLQACKMEGFPLVPPPSEDLVPYDTDLYQRQTHEYYPYLSSDGESHSDHYWDFHPHHVHSEFESFAENNFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHPSLGHQVSYLPRMCLQYPSLSPAQPSSDEEEGERQSPPLEVSDGEADGLEPGPGLLPGETGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLGRGGLAERRHPPH
Tissue specificity:
Induction:Highly expressed in both FV-P and FV-A-induced erythro-leukemia cell lines that have undergone rearrangements of the SPI1 gene due to the insertion of SFFV. Negatively regulated by microRNA-155 (miR-155). {ECO:0000269|PubMed:23166356}.
Developmental stage:
Protein families:ETS family