ASC_HUMAN Q9ULZ3
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UniProt:Q9ULZ3
Recommended name：Apoptosis-associated speck-like protein containing a CARD
EC number：
Alternative names：(hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)
Cleaved into：
GeneID：29108
Gene names (primary )：PYCARD
Gene names (synonym )：ASC CARD5 TMS1
Gene names (ORF )：
Length：195
Mass：21627
Sequence：MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS
Tissue specificity：Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Expressed in lung epithelial cells (at protein level) (PubMed:23229815). Detected in the leukemia cell lines HL-60 and U-937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and MOLT-4 lymphocytic leukemia cells. {ECO:0000269|PubMed:23229815}.
Induction：In macrophages, up-regulated by endocannabinoid anandamide/AEA. {ECO:0000269|PubMed:23955712}.
Developmental stage：
Protein families：