TREX1_HUMAN Q9NSU2
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UniProt:Q9NSU2
Recommended name：Three-prime repair exonuclease 1
EC number：EC:3.1.11.2
Alternative names：(3'-5' exonuclease TREX1) (Deoxyribonuclease III) (DNase III)
Cleaved into：
GeneID：11277
Gene names (primary )：TREX1
Gene names (synonym )：
Gene names (ORF )：
Length：314
Mass：33212
Sequence：MGSQALPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASARTKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLAVATLYGLSLATPGE
Tissue specificity：Detected in thymus, spleen, liver, brain, heart, small intestine and colon. {ECO:0000269|PubMed:10393201, ECO:0000269|PubMed:11278605}.
Induction：Induced by cytosolic DNA. Induced by inflammatory stimuli such as IFN-alpha and IFN-gamma in B cells and also by LPS and viral and bacterial DNA (via TLR9) in dendritic cells and macrophages (By similarity). {ECO:0000250}.
Developmental stage：
Protein families：Exonuclease superfamily, TREX family