LEP_HUMAN P41159
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UniProt:P41159
Recommended name:Leptin
EC number:
Alternative names:(Obese protein) (Obesity factor)
Cleaved into:
GeneID:3952
Gene names (primary ):LEP
Gene names (synonym ):OB OBS
Gene names (ORF ):
Length:167
Mass:18641
Sequence:MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGLDFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLPWASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC
Tissue specificity:Adipose tissue is the main source of leptin. It is also produced by other peripheral tissues such as the skeletal muscle (PubMed:7789654, PubMed:16052473, PubMed:12448771). Expressed by intercalated and striated tracts of submandibular and parotid salivary gland intralobular ducts (PubMed:12448771). Detected by fundic epithelium of the gastric mucosa (PubMed:10896907). Secreted into blood and gastric juice (PubMed:10896907). {ECO:0000269|PubMed:10896907, ECO:0000269|PubMed:12448771, ECO:0000269|PubMed:16052473, ECO:0000269|PubMed:7789654}.
Induction:Induced by secretin. {ECO:0000269|PubMed:10896907}.
Developmental stage:
Protein families:Leptin family