PANK1_HUMAN Q8TE04
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UniProt:Q8TE04
Recommended name：Pantothenate kinase 1
EC number：EC:2.7.1.33
Alternative names：(hPanK) (hPanK1) (Pantothenic acid kinase 1)
Cleaved into：
GeneID：53354
Gene names (primary )：PANK1
Gene names (synonym )：PANK
Gene names (ORF )：
Length：598
Mass：64339
Sequence：MLKLVGGGGGQDWACSVAGTSLGGEEAAFEVARPGDQGKAGGGSPGWGCAGIPDSAPGAGVLQAGAVGPARGGQGAEEVGESAGGGEERRVRHPQAPALRLLNRKPQGGSGEIKTPENDLQRGRLSRGPRTAPPAPGMGDRSGQQERSVPHSPGAPVGTSAAAVNGLLHNGFHPPPVQPPHVCSRGPVGGSDAAPQRLPLLPELQPQPLLPQHDSPAKKCRLRRRMDSGRKNRPPFPWFGMDIGGTLVKLVYFEPKDITAEEEQEEVENLKSIRKYLTSNTAYGKTGIRDVHLELKNLTMCGRKGNLHFIRFPSCAMHRFIQMGSEKNFSSLHTTLCATGGGAFKFEEDFRMIADLQLHKLDELDCLIQGLLYVDSVGFNGKPECYYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRDSISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGALLELFKMTDDK
Tissue specificity：[Isoform 1]: Expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis. {ECO:0000269|PubMed:14523052}.; [Isoform 2]: Detected at much lower levels in kidney, liver, brain and testis and not detected in heart or skeletal muscle. {ECO:0000269|PubMed:14523052}.
Induction：Isoform 1 is induced by bezafibrate, a hypolipidemic drug which acts as an agonist of peroxisome proliferator activator receptor alpha (PPARA), while isoform 2 levels decrease slightly. {ECO:0000269|PubMed:14523052}.
Developmental stage：
Protein families：Type II pantothenate kinase family