SESN1_HUMAN Q9Y6P5
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UniProt:Q9Y6P5
Recommended name：Sestrin-1
EC number：EC:1.11.1.-
Alternative names：(p53-regulated protein PA26)
Cleaved into：
GeneID：27244
Gene names (primary )：SESN1
Gene names (synonym )：PA26 SEST1
Gene names (ORF )：
Length：492
Mass：56557
Sequence：MRLAAAANEAYTAPLAVSGLLGCKQCGGGRDQDEELGIRIPRPLGQGPSRFIPEKEILQVGSEDAQMHALFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQCSYLVNLHVNDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMPVNSAENVSVSDSFFEVEALMEKMRQLQECRDEEEASQEEMASRFEIEKRESMFVFSSDDEEVTPARAVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT
Tissue specificity：Widely expressed. {ECO:0000269|PubMed:12607115}.
Induction：Isoform T2 and isoform T3 are induced by genotoxic stress (UV, gamma-irradiation and cytotoxic drugs) in a p53/TP53-dependent manner. Isoform T1 is not induced by p53/TP53. {ECO:0000269|PubMed:9926927}.
Developmental stage：
Protein families：Sestrin family