LN28B_HUMAN Q6ZN17
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UniProt:Q6ZN17
Recommended name：Protein lin-28 homolog B
EC number：
Alternative names：(Lin-28B)
Cleaved into：
GeneID：389421
Gene names (primary )：LIN28B
Gene names (synonym )：CSDD2
Gene names (ORF )：
Length：250
Mass：27084
Sequence：MAEGGASKGGGEEPGKLPEPAEEESQVLRGTGHCKWFNVRMGFGFISMINREGSPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGPGGSPCLGSERRPKGKTLQKRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHYCQSIMHMVANCPHKNVAQPPASSQGRQEAESQPCTSTLPREVGGGHGCTSPPFPQEARAEISERSGRSPQEASSTKSSIAPEEQSKKGPSVQKRKKT
Tissue specificity：Expressed at high levels in the placenta and, at mucher lower, in testis and fetal liver (PubMed:16971064). Isoform 1 is only detected in placenta and in moderately and poorly differentiated hepatocellular carcinoma cells (at protein level). Isoform 2 is detected in fetal liver, non-tumor liver tissues, as well as well-differentiated tumor tissues (at protein level). Tends to be up-regulated in triple-negative (ER-,PR-,HER2-) breast tumors, as well as in liver, ovarian, and thyroid carcinomas (PubMed:22118463). {ECO:0000269|PubMed:16971064, ECO:0000269|PubMed:22118463}.
Induction：Might be negatively regulated by the microRNA let-7b. {ECO:0000269|PubMed:16971064}.
Developmental stage：
Protein families：Lin-28 family