CLC4A_HUMAN Q9UMR7
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UniProt:Q9UMR7
Recommended name：C-type lectin domain family 4 member A
EC number：
Alternative names：(C-type lectin DDB27) (C-type lectin superfamily member 6) (Dendritic cell immunoreceptor) (Lectin-like immunoreceptor) (CD antigen CD367)
Cleaved into：
GeneID：50856
Gene names (primary )：CLEC4A
Gene names (synonym )：CLECSF6 DCIR LLIR
Gene names (ORF )：HDCGC13P
Length：237
Mass：27512
Sequence：MTSEITYAEVRFKNEFKSSGINTASSAASKERTAPHKSNTGFPKLLCASLLIFFLLLAISFFIAFVIFFQKYSQLLEKKTTKELVHTTLECVKKNMPVEETAWSCCPKNWKSFSSNCYFISTESASWQDSEKDCARMEAHLLVINTQEEQDFIFQNLQEESAYFVGLSDPEGQRHWQWVDQTPYNESSTFWHPREPSDPNERCVVLNFRKSPKRWGWNDVNCLGPQRSVCEMMKIHL
Tissue specificity：Expressed preferentially in hematopoietic tissues. Expressed in all circulating Ag-presenting cells such as dendritic cells, myeloid cells, monocytes, macrophages, B-cells and epidermal Langerhans cells (at protein level). Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. {ECO:0000269|PubMed:10438934, ECO:0000269|PubMed:11178971, ECO:0000269|PubMed:11994513, ECO:0000269|PubMed:18258799, ECO:0000269|PubMed:20530286}.
Induction：TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level) (PubMed:11994513). Expression is decreased in dendritic cells by signals inducing their maturation (e.g. CD40 ligand, TLR9 ligands, LPS, and TNF alpha) (PubMed:10438934, PubMed:18258799). Isoform 2: mRNA expression is up-regulated by agonists of neutrophils CSF2/GM-CSF, IL3/interleukin-3, IL4/interleukin-4 and IL13/interleukin-13 (PubMed:11994513). {ECO:0000269|PubMed:10438934, ECO:0000269|PubMed:11994513, ECO:0000269|PubMed:18258799}.
Developmental stage：
Protein families：