CCRL2_HUMAN O00421
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UniProt:O00421
Recommended name：C-C chemokine receptor-like 2
EC number：
Alternative names：(Chemokine receptor CCR11) (Chemokine receptor X) (Putative MCP-1 chemokine receptor)
Cleaved into：
GeneID：9034
Gene names (primary )：CCRL2
Gene names (synonym )：CCR11 CCR6 CKRX CRAM HCR
Gene names (ORF )：
Length：344
Mass：39513
Sequence：MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV
Tissue specificity：Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients. {ECO:0000269|PubMed:11828366, ECO:0000269|PubMed:15188357, ECO:0000269|PubMed:18397265, ECO:0000269|PubMed:9473515}.
Induction：Up-regulated by CCL5 on the pre-B-cell lines NALM-6 and G2. {ECO:0000269|PubMed:18397265}.
Developmental stage：
Protein families：G-protein coupled receptor 1 family