CLC6A_HUMAN   Q6EIG7


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UniProt:Q6EIG7

Recommended name:C-type lectin domain family 6 member A

EC number:

Alternative names:(C-type lectin superfamily member 10) (Dendritic cell-associated C-type lectin 2) (DC-associated C-type lectin 2) (Dectin-2)

Cleaved into:

GeneID:93978

Gene names  (primary ):CLEC6A

Gene names  (synonym ):CLECSF10 DECTIN2

Gene names  (ORF ):

Length:209

Mass:23998

Sequence:MMQEQQPQSTEKRGWLSLRLWSVAGISIALLSACFIVSCVVTYHFTYGETGKRLSELHSYHSSLTCFSEGTKVPAWGCCPASWKSFGSSCYFISSEEKVWSKSEQNCVEMGAHLVVFNTEAEQNFIVQQLNESFSYFLGLSDPQGNNNWQWIDKTPYEKNVRFWHLGEPNHSAEQCASIVFWKPTGWGWNDVICETRRNSICEMNKIYL

Tissue specificity:Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids. {ECO:0000269|PubMed:15175046, ECO:0000269|PubMed:15368084, ECO:0000269|PubMed:15810886}.

Induction:Up-regulated by granulocyte-macrophage colony-stimulating factor (GM-CSF), TGF-beta 1, TNF-alpha and down-regulated by IL-4, IL-10 or UVB in CD14+ monocytes. {ECO:0000269|PubMed:15810886}.

Developmental stage:

Protein families:


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