SESN2_HUMAN P58004
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UniProt:P58004
Recommended name：Sestrin-2
EC number：EC:1.11.1.-
Alternative names：(Hypoxia-induced gene)
Cleaved into：
GeneID：83667
Gene names (primary )：SESN2
Gene names (synonym )：Hi95 SEST2
Gene names (ORF )：
Length：480
Mass：54494
Sequence：MIVADSECRAELKDYLRFAPGGVGDSGPGEEQRESRARRGPRGPSAFIPVEEVLREGAESLEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHYLLLHTDGPLASSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTGEHTWSLAELIQALVLLTHCHSLSSFVFGCGILPEGDADGSPAPQAPTPPSEQSSPPSRDPLNNSGGFESARDVEALMERMQQLQESLLRDEGTSQEEMESRFELEKSESLLVTPSADILEPSPHPDMLCFVEDPTFGYEDFTRRGAQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKTTRRMYNLFWRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYMT
Tissue specificity：Widely expressed. {ECO:0000269|PubMed:12607115}.
Induction：Up-regulated by hypoxia and DNA damage (PubMed:12203114). Up-regulated by treatments inducing endoplasmic reticulum stress (PubMed:24947615). {ECO:0000269|PubMed:12203114, ECO:0000269|PubMed:24947615}.
Developmental stage：
Protein families：Sestrin family