ADA_HUMAN P00813
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UniProt:P00813
Recommended name:Adenosine deaminase
EC number:EC:3.5.4.4
Alternative names:(Adenosine aminohydrolase)
Cleaved into:
GeneID:100
Gene names (primary ):ADA
Gene names (synonym ):ADA1
Gene names (ORF ):
Length:363
Mass:40764
Sequence:MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL
Tissue specificity:Found in all tissues, occurs in large amounts in T-lymphocytes (PubMed:20959412). Expressed at the time of weaning in gastrointestinal tissues. {ECO:0000269|PubMed:20959412}.
Induction:Up-regulated by hypoxia. {ECO:0000269|PubMed:16670267}.
Developmental stage:
Protein families:Metallo-dependent hydrolases superfamily, Adenosine and AMP deaminases family