DHRS2_HUMAN Q13268
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UniProt:Q13268
Recommended name：Dehydrogenase/reductase SDR family member 2, mitochondrial
EC number：EC:1.1.1.-
Alternative names：(Dicarbonyl reductase HEP27) (Protein D) (Short chain dehydrogenase/reductase family 25C member 1)
Cleaved into：
GeneID：10202
Gene names (primary )：DHRS2
Gene names (synonym )：SDR25C1
Gene names (ORF )：
Length：280
Mass：29927
Sequence：MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNGENIAVAGYSTRL
Tissue specificity：Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes. {ECO:0000269|PubMed:11944995}.
Induction：Up-regulated by IL4 and CSF2 in monocytes/macrophages. Down-regulated by bacterial lipopolysaccharides (LPS) and TNF in monocytice-derived dendritic cells. Up-regulated by MYB. {ECO:0000269|PubMed:11944995}.
Developmental stage：
Protein families：Short-chain dehydrogenases/reductases (SDR) family