NKG2D_HUMAN   P26718


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UniProt:P26718

Recommended name:NKG2-D type II integral membrane protein

EC number:

Alternative names:(Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)

Cleaved into:

GeneID:100528032

Gene names  (primary ):KLRK1

Gene names  (synonym ):D12S2489E NKG2D

Gene names  (ORF ):

Length:216

Mass:25274

Sequence:MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCRENASPFFFCCFIAVAMGIRFIIMVAIWSAVFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV

Tissue specificity:Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs). {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:15294961, ECO:0000269|PubMed:16444266}.

Induction:Up-regulated by interleukin IL15 in primary NK cells. {ECO:0000269|PubMed:11777960}.

Developmental stage:

Protein families:


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