TIGAR_HUMAN Q9NQ88
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UniProt:Q9NQ88
Recommended name：Fructose-2,6-bisphosphatase TIGAR
EC number：EC:3.1.3.46
Alternative names：(TP53-induced glycolysis and apoptosis regulator) (TP53-induced glycolysis regulatory phosphatase)
Cleaved into：
GeneID：57103
Gene names (primary )：TIGAR
Gene names (synonym )：C12orf5
Gene names (ORF )：
Length：270
Mass：30063
Sequence：MARFALTVVRHGETRFNKEKIIQGQGVDEPLSETGFKQAAAAGIFLNNVKFTHAFSSDLMRTKQTMHGILERSKFCKDMTVKYDSRLRERKYGVVEGKALSELRAMAKAAREECPVFTPPGGETLDQVKMRGIDFFEFLCQLILKEADQKEQFSQGSPSNCLETSLAEIFPLGKNHSSKVNSDSGIPGLAASVLVVSHGAYMRSLFDYFLTDLKCSLPATLSRSELMSVTPNTGMSLFIINFEEGREVKPTVQCICMNLQDHLNGLTETR
Tissue specificity：Expressed in the brain (PubMed:22887998). Expressed in breast tumors (PubMed:21820150). Expressed in glioblastomas (PubMed:22887998). {ECO:0000269|PubMed:21820150, ECO:0000269|PubMed:22887998}.
Induction：Up-regulated by p53/TP53 (at protein level) (PubMed:16839880). Rapidly up-regulated by p53/TP53 (PubMed:16140933, PubMed:16839880, PubMed:19713938). Up-regulated in glioma cell line in a p53/TP53-independent manner (PubMed:22887998). {ECO:0000269|PubMed:16140933, ECO:0000269|PubMed:16839880, ECO:0000269|PubMed:19713938, ECO:0000269|PubMed:22887998}.
Developmental stage：
Protein families：Phosphoglycerate mutase family