ULK3_HUMAN Q6PHR2
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UniProt:Q6PHR2
Recommended name:Serine/threonine-protein kinase ULK3
EC number:EC:2.7.11.1
Alternative names:(Unc-51-like kinase 3)
Cleaved into:
GeneID:25989
Gene names (primary ):ULK3
Gene names (synonym ):
Gene names (ORF ):
Length:472
Mass:53444
Sequence:MAGPGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLGRATALVVQAVKKDQEGDSAAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGTSARDLLREMARDKPRLLAALEVASAAMAKEEAAGGEQDALDLYQHSLGELLLLLAAEPPGRRRELLHTEVQNLMARAEYLKEQVKMRESRWEADTLDKEGLSESVRSSCTLQ
Tissue specificity:Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord. {ECO:0000269|PubMed:19878745}.
Induction:Up-regulated during senescence. {ECO:0000269|PubMed:19279323}.
Developmental stage:
Protein families:Protein kinase superfamily, Ser/Thr protein kinase family, APG1/unc-51/ULK1 subfamily