DERL3_HUMAN Q96Q80
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UniProt:Q96Q80
Recommended name:Derlin-3
EC number:
Alternative names:(Degradation in endoplasmic reticulum protein 3) (DERtrin-3) (Der1-like protein 3)
Cleaved into:
GeneID:91319
Gene names (primary ):DERL3
Gene names (synonym ):C22orf14 DER3 LLN2
Gene names (ORF ):
Length:235
Mass:26679
Sequence:MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTNFLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFLGQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGHIYYFLEDVFPNQPGGKRLLQTPGFLKLLLDAPAEDPNYLPLPEEQPGPHLPPPQQ
Tissue specificity:Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine. {ECO:0000269|PubMed:16449189}.
Induction:Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR). {ECO:0000269|PubMed:16449189}.
Developmental stage:
Protein families:Derlin family