RNAS7_HUMAN Q9H1E1
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UniProt:Q9H1E1
Recommended name：Ribonuclease 7
EC number：EC:3.1.27.-
Alternative names：(RNase 7) (Skin-derived antimicrobial protein 2) (SAP-2)
Cleaved into：
GeneID：84659
Gene names (primary )：RNASE7
Gene names (synonym )：
Gene names (ORF )：UNQ2516/PRO6006
Length：156
Mass：17419
Sequence：MAPARAGFCPLLLLLLLGLWVAEIPVSAKPKGMTSSQWFKIQHMQPSPQACNSAMKNINKHTKRCKDLNTFLHEPFSSVAATCQTPKIACKNGDKNCHQSHGAVSLTMCKLTSGKHPNCRYKEKRQNKSYVVACKPPQKKDSQQFHLVPVHLDRVL
Tissue specificity：Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level) (PubMed:25075772). Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut (PubMed:12244054). Expressed in liver, kidney, skeletal muscle and heart (PubMed:12527768). {ECO:0000269|PubMed:12244054, ECO:0000269|PubMed:12527768, ECO:0000269|PubMed:25075772}.
Induction：Up-regulated in response to the cytokines IL1B, IFNG and TNF (PubMed:12244054). Strongly up-regulated in response to the bacterium P.aeruginosa (PubMed:12244054). Moderately up-regulated in response to S.aureus, E.coli and S.pyogenes (PubMed:12244054). Up-regulated in kidney in response to infection (PubMed:25075772). {ECO:0000269|PubMed:12244054, ECO:0000269|PubMed:25075772}.
Developmental stage：
Protein families：Pancreatic ribonuclease family