FBX5_HUMAN Q9UKT4
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UniProt:Q9UKT4
Recommended name：F-box only protein 5
EC number：
Alternative names：(Early mitotic inhibitor 1)
Cleaved into：
GeneID：26271
Gene names (primary )：FBXO5
Gene names (synonym )：EMI1 FBX5
Gene names (ORF )：
Length：447
Mass：50146
Sequence：MSRRPCSCALRPPRCSCSASPSAVTAAGRPRPSDSCKEESSTLSVKMKCDFNCNHVHSGLKLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVQLETESKRLHNKENQHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENFGDSLQSCLLQIQSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNFRLQNIIGRKMGLECVDILSELFRRGLRHVLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQRVTENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHNEFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTKDCSDGKLLKASCKIGPLPGTKKSKKNLRRL
Tissue specificity：
Induction：Up-regulated at 7 days after osteogenic induction (PubMed:29850565). Down-regulated in late G2 phase or mitosis (PubMed:17485488). Down-regulated in G2 phase after DNA damage in a CDKN1A-dependent manner (PubMed:19211842). Down-regulated in G1 phase when APC-FZR1 complex is active and accumulates at the G1-S transition, coincident with the inactivation of APC-FZR1 complex (PubMed:29875408). At the G1-S transition, transcriptionally induced by the E2F transcription factor (PubMed:11988738). {ECO:0000269|PubMed:11988738, ECO:0000269|PubMed:17485488, ECO:0000269|PubMed:19211842, ECO:0000269|PubMed:29850565, ECO:0000269|PubMed:29875408}.
Developmental stage：Accumulates in late G1 phase, levels rise during S phase and drop in early mitosis. {ECO:0000269|PubMed:11988738}.
Protein families：