HBG1_HUMAN P69891
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UniProt:P69891
Recommended name：Hemoglobin subunit gamma-1
EC number：
Alternative names：(Gamma-1-globin) (Hb F Agamma) (Hemoglobin gamma-1 chain) (Hemoglobin gamma-A chain)
Cleaved into：
GeneID：3047
Gene names (primary )：HBG1
Gene names (synonym )：
Gene names (ORF )：PRO2979
Length：147
Mass：16140
Sequence：MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPENFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTAVASALSSRYH
Tissue specificity：Red blood cells.
Induction：By 5-azacytidine. {ECO:0000269|PubMed:16131492}.
Developmental stage：Expressed until four or five weeks after birth. Detected at very low levels in adults, where it constitutes about 1% of the total hemoglobin. In contrast, the levels of fetal hemoglobin F (two alpha chains and two gamma chains) are increased in children and adults with beta-thalassemia or sickle-cell disease. In cases of homozygous alpha-thalassemia, homotetrameric hemoglobin Bart's is highly expressed and is the predominant form of hemoglobin after 10 weeks of gestation. Its levels increase steadily after 10 weeks of gestation and until birth (at protein level). {ECO:0000269|PubMed:20925047, ECO:0000269|PubMed:21747884, ECO:0000269|PubMed:22096240}.
Protein families：Globin family