PTGDS_HUMAN P41222
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UniProt:P41222
Recommended name：Prostaglandin-H2 D-isomerase
EC number：EC:5.3.99.2
Alternative names：(Beta-trace protein) (Cerebrin-28) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (L-PGDS) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS) (PGDS2)
Cleaved into：
GeneID：5730
Gene names (primary )：PTGDS
Gene names (synonym )：PDS
Gene names (ORF )：
Length：190
Mass：21029
Sequence：MATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAGSLGSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFLPQTDKCMTEQ
Tissue specificity：Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prostate, and is secreted into the seminal fluid. Expressed in the eye and secreted into the aqueous humor. Lower levels detected in various tissue fluids such as serum, normal urine, ascitic fluid and tear fluid. Also found in a number of other organs including ovary, fimbriae of the fallopian tubes, kidney, leukocytes. {ECO:0000269|PubMed:10462696, ECO:0000269|PubMed:11882588, ECO:0000269|PubMed:7692978, ECO:0000269|PubMed:8599604, ECO:0000269|PubMed:8761996, ECO:0000269|PubMed:9065498, ECO:0000269|PubMed:9405674, ECO:0000269|PubMed:9475419, ECO:0000269|PubMed:9844724}.
Induction：By IL1B/interleukin-1 beta and thyroid hormone. Probably induced by dexamethasone, dihydrotestosterone (DHT), progesterone, retinoic acid and retinal. Repressed by the Notch-Hes signaling pathway. {ECO:0000269|PubMed:9162076}.
Developmental stage：Expression in the amniotic fluid increases dramatically during weeks 12 to 25 of pregnancy. Levels decrease slowly after 25 weeks. {ECO:0000269|PubMed:8674187}.
Protein families：Calycin superfamily, Lipocalin family