ENK18_HUMAN O42043
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UniProt:O42043
Recommended name：Endogenous retrovirus group K member 18 Env polyprotein
EC number：
Alternative names：(Envelope polyprotein) (HERV-K(C1a) envelope protein) (HERV-K110 envelope protein) (HERV-K18 envelope protein) (HERV-K18 superantigen) (HERV-K_1q23.3 provirus ancestral Env polyprotein) (IDDMK1,2 22 envelope protein) (IDDMK1,2 22 superantigen)
Cleaved into：Surface protein (SU); Transmembrane protein (TM)
GeneID：
Gene names (primary )：ERVK-18
Gene names (synonym )：
Gene names (ORF )：
Length：560
Mass：63671
Sequence：MVTPVTWMDNPIEVYVNDSVWVPGPTDDRCPAKPEEEGMMINISIGYHYPPICLGRAPGCLMPAVQNWLVEVPTVSPNSRFTYHMVSGMSLRPRVNCLQDFSYQRSLKFRPKGKTCPKEIPKGSKNTEVLVWEECVANSVVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCPSAQVSPAVDSDLTESLDKHKHKKLQSFYLWEWEEKGISTPRPKIISPVSGPEHPELWRLTVASHHIRIWSGNQTLETRYRKPFYTIDLNSILTVPLQSCVKPPYMLVVGNIVIKPASQTITCENCRLFTCIDSTFNWQHRILLVRAREGMWIPVSTDRPWEASPSIHILTEILKGVLNRSKRFIFTLIAVIMGLIAVTATAAVAGVALHSSVQSVNFVNYWQKNSTRLWNSQSSIDQKLASQINDLRQTVIWMGDRLMTLEHHFQLQCDWNTSDFCITPQIYNESEHHWDMVRRHLQGREDNLTLDISKLKEQIFEASKAHLNLVPGTEAIAGVADGLANLNPVTWIKTIRSTMIINLILIVVCLFCLLLVCRCTQQLRRDSDIENGP
Tissue specificity：Expressed at higher level in the thymus. Expressed at lower level in peripheral blood lymphocytes.
Induction：Induced by type I interferons and by Epstein-Barr virus (EBV). {ECO:0000269|PubMed:11672541}.
Developmental stage：High expression in thymocytes. Neither expressed nor inducible in mature T-cells. Inducible in CD2 negative peripheral blood lymphocytes.
Protein families：Beta type-B retroviral envelope protein family, HERV class-II K(HML-2) env subfamily